ADS Day for Phenytoin, Digoxin, CAP/VAP/HAP

  • CKD causes the displacement of Phenytoin, be cautious in patients with CKD who are experiencing a seizure
  • For Digoxin when you double the dose you will double the level
  • Levels for Phenytoin should be ordered 2-4 hours post IV load, Maintenance level should be ordered at steady state which occurs at 7-21 days
  • In Canada we do not have high incidences of atypical infections and we cannot identify them in the lab, except for urine antigen test for legionella
  • On antibiograms <80 = a high failure rate with antibiotics
  • Clarithromycin causes more drug-drug interactions compared to other macrolides

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